It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Your doctor will tell you if you need to use the medicines for longer than 26 weeks. Alcohol may increase the risk of liver disease.

Properly discard this product when it is expired or no longer needed. Read the Medication Guide provided by your pharmacist before you start taking pretomanid and each time you get a refill. Selected from data included with permission and copyright by First DataBank, Inc.

Examples include efavirenz, rifamycins (such as rifampin, rifabutin), St. John's wort, drugs used to treat seizures (such as carbamazepine, phenytoin), among others. Many people using this medication do not have serious side effects. Avoid combination, Deferasirox: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers).

The information in not intend to cover all possible uses, directions, precautions, drug interactions or adverse effects nor should it be construed in indicate that use of a particular drug is safe, appropriate or effective for you or anyone else.

QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away. This medication is used in combination with certain other medications (such as bedaquiline, linezolid) to treat active multi-drug-resistant tuberculosis (TB) of the lungs in certain people. If your doctor tells you to stop taking the antibiotic combination, follow all instructions for taking the missed doses at the end of your treatment. Nausea, upset stomach, diarrhea, cough, muscle/joint pain, acne, and headache may occur. If you miss a dose, take it as soon as you remember. Avoid alcoholic beverages while using this combination of medications. Listen to the audio pronunciation of Pretomanid on pronouncekiwi. You may report side effects to FDA at 1-800-FDA-1088. If linezolid is discontinued after the initial 4 weeks of consecutive treatment, pretomanid in combination with bedaquiline only may be continued. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you notice other effects not listed above, contact your doctor or pharmacist. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Otherwise, call a poison control center right away. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Last updated on Apr 12, 2020. Sometimes it is not safe to use certain medications at the same time. Monitor visual function. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Pretomanid is not approved for use by anyone younger than 18 years old. This antibiotic treats only bacterial infections. Limitations of use: Not indicated for drug-sensitive tuberculosis, latent infection due to Mycobacterium tuberculosis, or multidrug-resistant TB that is not treatment-intolerant or nonresponsive to standard therapy. Get medical help right away if you develop any rash. Discontinuation of therapy: If pretomanid or bedaquiline is discontinued or if linezolid is permanently discontinued during the initial 4 consecutive weeks of treatment, the entire regimen should be discontinued.

Monitor therapy.

Consult drug interactions database for more detailed information. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. Obtain serum calcium, magnesium, and potassium at baseline; correct if abnormal and repeat testing if QT prolongation occurs. • Hepatic effects: Hepatic adverse reactions have been reported with pretomanid in combination with bedaquiline and linezolid. Dispense only in original container.

This is a summary and does NOT have all possible information about this product.

You may report side effects to Health Canada at 1-866-234-2345. Discuss the risks and benefits with your doctor. During week 3 through week 26, only pretomanid and linezolid are taken daily and bedaquiline is taken 3 times per week, at least 48 hours apart.

Monitor therapy, OAT1/3 Substrates: Pretomanid may increase the serum concentration of OAT1/3 Substrates. Call your doctor for instructions if you miss a dose of pretomanid, bedaquiline, or linezolid. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. To help you remember, take this medication at the same time every day. long QT syndrome (in you or a family member); low levels of calcium, potassium, or magnesium in your blood. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. This copyrighted material has been downloaded from a licensed ata provider and is not for distribution, except as may be authorized by the applicable terms of use. As reported in combination with bedaquiline and linezolid. Alcohol (Ethyl): May enhance the hepatotoxic effect of Pretomanid. Pretomanid is taken with food and a glass of water. This information is not individual medical advice and does not substitute for the advice of your health care professional. Ask your doctor about any risk. Older adults may be more sensitive to the side effects of this drug, especially QT prolongation (see above). Download the NorthShoreConnect app to access your health information on your mobile phone. All Rights Reserved. Monitor visual function in all patients; if a patient experiences symptoms of visual impairment, interrupt linezolid dosing and promptly obtain an ophthalmologic evaluation. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. Talk to your doctor if you have questions. A very serious allergic reaction to this drug is rare. Using any antibiotic when it is not needed can cause it to not work for future infections. Immediately evaluate patients who develop recurrent nausea or vomiting, including assessment of bicarbonate and lactic acid levels, and consider interruption of treatment with linezolid or the entire regimen. • QT prolongation: QT prolongation was reported with pretomanid in combination with bedaquiline and linezolid. You will need frequent blood tests to check your blood cells and liver function before and during treatment with this medicine.

Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Treatment may be extended beyond 26 weeks if necessary. • Drug-drug interactions: Potentially significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapy. NorthShore University HealthSystem. QT prolongation is a known adverse reaction of bedaquiline. fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out); tremors, weakness, problems with balance; shortness of breath, chest pain that gets worse when you breathe or cough; heartburn, stomach pain, loss of appetite, nausea, vomiting, diarrhea; abnormal blood tests that check the function of your liver or pancreas. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information.

Store <30°C (86°F).

Conditions of use: The information in this database is intended to supplement, not substitute for the expertise and judgment of healthcare professionals. During the first 2 weeks, all 3 medications are taken daily. However, having tuberculosis during pregnancy may cause serious complications in both the mother and the baby. Keep the bottle tightly closed when not in use. Talk to your pharmacist for more details. Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Keep all medications away from children and pets. This is only a brief summary of general information about this medicine. Use all 3 medicines as directed and read all medication guides you receive. Monitor therapy, Erdafitinib: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). View the latest information on Coronavirus (COVID-19). Tuberculosis: Treatment of pulmonary extensively drug resistant or treatment-intolerant or nonresponsive multidrug-resistant tuberculosis (TB), as part of a combination regimen with bedaquiline and linezolid, in adult patients.